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Symbol Name ID |
Pten
phosphatase and tensin homolog MGI:109583 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Decreased circulating antibody level |
Lymphopenia |
Splenomegaly |
Recurrent otitis media |
Thyroiditis |
Hashimoto thyroiditis |
Recurrent infections |
| Disease(s) Associated with PTEN | |||||||
| Bannayan-Riley-Ruvalcaba syndrome | |||||||
| macrocephaly-autism syndrome |
| Mouse Phenotypes | immune system phenotype |
increased B cell apoptosis |
abnormal macrophage chemotaxis |
increased B cell proliferation |
decreased uterine NK cell number |
enlarged thymus |
prostate gland inflammation |
enlarged spleen |
increased spleen weight |
spleen hyperplasia |
abnormal B cell negative selection |
abnormal class switch recombination |
increased neutrophil cell number |
increased granulocyte number |
increased germinal center B cell number |
increased B-1 B cell number |
increased marginal zone B cell number |
decreased B cell number |
increased B cell number |
increased T follicular helper cell number |
decreased T cell number |
decreased lymphocyte cell number |
increased macrophage cell number |
increased monocyte cell number |
increased leukocyte cell number |
abnormal plasma cell morphology |
abnormal alveolar macrophage morphology |
decreased spleen germinal center number |
abnormal neutrophil physiology |
impaired neutrophil recruitment |
abnormal B cell physiology |
increased IgG1 level |
decreased IgG level |
increased IgM level |
abnormal CD8-positive, alpha-beta T cell physiology |
abnormal microglial cell physiology |
abnormal cytokine level |
enlarged Peyer's patches |
abnormal lymph node B cell domain morphology |
enlarged lymph nodes |
lymph node hyperplasia |
lymphoid hyperplasia |
decreased interleukin-2 secretion |
liver inflammation |
pyelonephritis |
lung inflammation |
decreased susceptibility to bacterial infection |
decreased susceptibility to bacterial infection induced morbidity/mortality |
increased susceptibility to bacterial infection |
increased susceptibility to bacterial infection induced morbidity/mortality |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Ptentm1Engc/Ptentm1Engc | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Ptentm1.1Hwu/Pten+ | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Ptentm1Mak/Pten+ | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Ptentm1Rps/Pten+ | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn Ptentm1Hwu/Ptentm1Hwu (conditional) |
* | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Ptentm1Hwu/Ptentm1Hwu Tg(Pbsn-cre)4Prb/0 (conditional) |
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| Cd19tm1(cre)Cgn/Cd19+ Ptentm1Hwu/Ptentm1Hwu (conditional) |
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| Ptentm1Hwu/Ptentm1Hwu Tg(Fabp4-cre)1Abel/0 (conditional) |
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| Ptentm1Hwu/Ptentm1Hwu Lyz2tm1(cre)Ifo/Lyz2+ (conditional) |
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| Ptentm1Hwu/Ptentm1Hwu Tg(Mx1-cre)1Cgn/0 (conditional) |
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| Ptentm1Hwu/Ptentm1Hwu Tg(Cdh5-cre)7Mlia/0 (conditional) |
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| Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ Ptentm1Hwu/Ptentm1Hwu (conditional) |
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| Amhr2tm3(cre)Bhr/Amhr2+ Ptentm1Hwu/Ptentm1Hwu (conditional) |
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| Ptentm1Hwu/Ptentm1Hwu Tg(GZMB-cre)1Jcb/0 (conditional) |
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| Ptentm1Hwu/Ptentm1Hwu Tg(CD2-icre)4Kio/0 (conditional) |
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| Ptentm2.1Ppp/Ptentm2.1Ppp Tnfrsf4tm2(cre)Nik/Tnfrsf4+ (conditional) |
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| Ptentm2Mak/Ptentm2Mak Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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